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autologous bone marrow mesenchymal stem cells
- Development stage
- Unknown
- Lead developer
- Apeiron Research Center
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intranasal, Intravenous
01
Overview
This autologous cell therapy consists of mesenchymal stem cells (MSCs) derived from a patient's own bone marrow, currently under investigation by the Apeiron Research Center in collaboration with the University of Colorado Boulder for the treatment of Parkinson's disease and atypical parkinsonism (Parkinson-Plus Syndrome). The therapeutic process involves harvesting bone marrow aspirate from the patient's pelvis, isolating and concentrating the MSCs in a specialized laboratory, and re-administering them through a combination of intranasal (aerosolized) and intravenous routes. The biological mechanism is centered on the cells' ability to modulate immune responses, secrete anti-inflammatory and neurotrophic factors, and potentially promote tissue repair or replace damaged neurons within the central nervous system to mitigate neurodegeneration.
- Other names
- BM-MSCsautologous mesenchymal stem cellsINA BMACIV BMAbone marrow-derived mesenchymal stem cells
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