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autologous bone marrow mesenchymal stem cells (LifeStem)
- Development stage
- Unknown
- Lead developer
- LifeStem
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intrathecal, Intralesional
01
Overview
Autologous bone marrow mesenchymal stem cells is a cell therapy developed by LifeStem for the treatment of spinal cord injuries (SCI). The procedure involves harvesting mesenchymal stem cells from the patient's own bone marrow, expanding them ex vivo, and then transplanting them back into the patient at the site of injury. The therapy aims to promote neurological regeneration and functional recovery through several mechanisms, including the secretion of neurotrophic and growth factors, immunomodulation of the injury environment, and potential differentiation into neural-like cells. Clinical investigation, notably trial NCT00816803, has focused on patients with chronic and complete spinal cord injuries at various levels (cervical, thoracic, and lumbar), utilizing administration routes such as direct intralesional injection or intrathecal delivery.
- Other names
- BMMSCsautologous bone marrow-derived mesenchymal stem cellsautologous BM-MSCs
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