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autologous bone marrow mononuclear cells (Red Andaluza de Terapias Avanzadas)
- Development stage
- Unknown
- Lead developer
- Red Andaluza de Terapias Avanzadas
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intra-arterial
01
Overview
Autologous bone marrow mononuclear cells (BM-MNCs) are a heterogeneous population of cells, including hematopoietic stem cells, mesenchymal stem cells, and endothelial progenitor cells, harvested from a patient's own bone marrow. Developed by the Andalusian Initiative for Advanced Therapies for the treatment of acute ischemic stroke, these cells are administered intra-arterially to the affected brain region. The therapeutic effect is primarily attributed to paracrine mechanisms, where the cells secrete various neurotrophic, angiogenic, and anti-inflammatory factors that promote neuroprotection, stimulate revascularization, and modulate the immune response to injury, thereby potentially improving functional recovery in stroke patients.
- Other names
- BM-MNCsBMMNCsautologous bone marrow-derived mononuclear cells
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