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autologous bone marrow mononuclear cells (900th Hospital of Joint Logistics Support Force of PLA)
- Development stage
- Unknown
- Lead developer
- 900th Hospital of Joint Logistics Support Force of PLA
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intra-arterial
01
Overview
Autologous bone marrow mononuclear cells (BM-MNCs) are an investigational cell therapy developed by Fuzhou General Hospital for the treatment of type 2 diabetes mellitus. The therapy involves harvesting a patient's own bone marrow, isolating the mononuclear cell fraction (which includes hematopoietic stem cells, mesenchymal stem cells, and progenitor cells), and infusing them directly into the pancreas via intra-arterial pancreatic infusion. This approach aims to promote the regeneration of insulin-producing β-cells and improve the local microenvironment through the release of paracrine factors and cytokines. In clinical studies, this cell therapy has been evaluated both as a monotherapy and in combination with hyperbaric oxygen therapy (HOT) to enhance cell survival and functional recovery.
- Other names
- BM-MNCautologous BM-MNCsbone marrow mononuclear cells
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