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autologous bone marrow mononuclear cells (Andalusian Initiative for Advanced Therapies)
- Development stage
- Unknown
- Lead developer
- Andalusian Progress and Health Public Foundation
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intracoronary
01
Overview
This is an investigational autologous cell therapy consisting of mononuclear cells derived from the patient's own bone marrow (BMMNCs), developed by the Andalusian Initiative for Advanced Therapies. The therapy is designed as an advanced therapy medicinal product (ATMP) for intracoronary infusion. It is primarily indicated for patients with chronic total coronary artery occlusions (CTO) who exhibit persistent left ventricular dysfunction (LVEF < 45%) following successful percutaneous revascularization. The mechanism of action relies on the regenerative potential of the bone marrow-derived cells, which are thought to stimulate neovascularization and myocardial tissue repair through paracrine signaling and direct cellular contribution, thereby improving cardiac function and preventing further ventricular remodeling.
- Other names
- BMMNCsautologous bone marrow-derived mononuclear cellsmononuclear cells from autologous bone marrow
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