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Drug intelligence / Profile preview
Autologous CD19-BCMA dual-target CAR T-cell therapy
- Development stage
- Phase 1
- Lead developer
- Beijing Gaobo Boren Hospital
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
Autologous CD19-BCMA dual-target CAR T-cell therapy is a personalized cell-based immunotherapy developed by Beijing Boren Hospital for the treatment of relapsed or refractory autoimmune diseases. The therapy involves the genetic modification of a patient's own T cells to express chimeric antigen receptors (CARs) that target both CD19, found on B-cell lineages, and B-cell maturation antigen (BCMA), found on plasma cells and plasmablasts. Utilizing an OR gate logic, the CAR T cells are activated upon encountering either antigen, facilitating a more comprehensive depletion of pathogenic B-cell populations than single-target therapies. It is currently being investigated in Phase 1 clinical trials for conditions such as systemic lupus erythematosus, systemic sclerosis, and idiopathic inflammatory myopathy.
- Other names
- Autologous CD19-BCMA dual-target CAR T-cell therapyCD19-BCMA dual-target CAR-TCD-19-BCMA dual-target CAR-TCD 19-BCMA dual-target CAR-T
02
Targets
BCMA (B-cell maturation antigen)CD19 (B lymphocyte antigen CD19)
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