Drug intelligence / Profile preview

autologous conditioned plasma

Development stage
Phase 4
Lead developer
Arthrex
Administration
Intraarticular, Intratendinous, Intramuscular, Intradermal, Topical
01

Overview

Autologous conditioned plasma (ACP) is a form of regenerative medicine that uses a patient's own blood components to promote healing. It's a type of platelet-rich plasma (PRP) therapy that concentrates platelets and growth factors from the patient's blood plasma to accelerate the natural healing process. ACP is created by drawing blood from the patient, processing it through centrifugation to separate and concentrate platelets, and then injecting this concentrated plasma into the injured or damaged area. The high concentration of platelets and growth factors in ACP stimulates tissue repair, reduces inflammation, and enhances the body's natural healing mechanisms[1][2][3]. The primary applications of ACP include treating orthopedic conditions (such as osteoarthritis, tendinopathy, and sports injuries), promoting wound healing, and supporting tissue regeneration[4][6]. It's also used in dermatology, cosmetic procedures, and dental/maxillofacial surgery[6]. A key advantage of ACP is that it uses the patient's own blood, eliminating the risk of immune rejection or adverse reactions that might occur with donor materials[6]. The concentrated growth factors in ACP can be 5-10 times greater than in standard blood samples, providing potent healing properties[5]. The ACP preparation process typically involves: 1. Blood collection from the patient 2. Centrifugation to separate blood components 3. Isolation of the plasma containing concentrated platelets and growth factors 4. Injection of the concentrated plasma into the treatment area[4][7] The entire process usually takes less than an hour and is minimally invasive[4]. Clinical Applications include: - Osteoarthritis pain relief - Tendinopathy and tenosynovitis - Muscle-fascial injuries - Wound care and healing - Post-surgical healing - General inflammation reduction[4][6]

Other names
ACPplatelet-rich plasmaPRP
02

Targets

EGFR (Epidermal growth factor receptor)IGF-1R (Insulin-like growth factor 1 receptor)IL1R1 (Interleukin-1 Receptor Type 1)PDGFRA (Platelet-derived growth factor receptor alpha)TGFBR (TGF-beta receptor)IL-1R (Interleukin-1 receptor type 1 (IL-1R1))

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