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autologous dendritic cell-leukemic cell fusion vaccine
- Development stage
- Unknown
- Lead developer
- Beth Israel Deaconess Medical Center
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
Autologous dendritic cell-leukemic cell fusion vaccine is a personalized **therapeutic cancer vaccine** developed in a Boston Medical Center-led acute myeloid leukemia program. It is manufactured individually by generating dendritic cells from the patient's peripheral-blood mononuclear cells ex vivo and fusing them with the patient's own AML blasts. The resulting hybrid fusion cells present a broad repertoire of patient-specific leukemia-associated antigens together with dendritic-cell antigen-presentation and co-stimulatory functions, with the aim of inducing polyclonal leukemia-reactive T-cell immunity, eliminating residual AML cells, and reducing relapse after chemotherapy-induced remission. The Boston Medical Center phase I study evaluated dose and safety in AML patients in first remission.
- Other names
- autologous dendritic cell-tumor fusion vaccinedendritic/leukemic fusion cell vaccinedendritic cell/acute myeloid leukemia fusion vaccineDC/AML fusion vaccine
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