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Drug intelligence / Profile preview
autologous dinitrophenyl-modified ovarian cancer vaccine
- Development stage
- Phase 2
- Lead developer
- AVAX Technologies
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intradermal
01
Overview
**OVax** is an investigational personalized therapeutic cancer vaccine developed by AVAX Technologies for relapsed advanced ovarian cancer. It is manufactured from a patient's own surgically obtained ovarian tumor cells, which are modified with the hapten 2,4-dinitrophenol to increase immunogenicity. The intended mechanism is induction of cellular antitumor immunity, including cytotoxic T-lymphocyte responses against patient-specific ovarian tumor antigens. OVax was evaluated in a Phase 1/2 study in patients with relapsed stage III or IV ovarian carcinoma, including platinum-resistant disease. ([cancer.gov](https://www.cancer.gov/publications/dictionaries/cancer-drug/def/autologous-dinitrophenyl-modified-ovarian-cancer-vaccine))
- Brand names
- OVax
- Other names
- autologous DNP-modified ovarian cancer vaccineDNP-conjugated autologous ovarian tumor cell vaccine antigenO-Vax
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