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autologous dual-target CAR-T cells (Beijing Biotech)
- Development stage
- Phase 2
- Lead developer
- Immunochina Pharmaceuticals
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies
- Administration
- Intravenous
01
Overview
Autologous dual-target CAR-T cell therapy is an experimental cellular immunotherapy developed by Beijing Biotech (Beijing Immunochina) for the treatment of advanced solid tumors. This therapy utilizes a biomarker-guided approach where a patient's tumor is screened for specific antigens, and the most appropriate dual-target CAR-T construct is selected from a predefined library. By targeting two tumor-associated antigens simultaneously, the therapy aims to enhance tumor specificity, overcome antigen heterogeneity, and mitigate the risk of antigen escape, which are common challenges in treating solid malignancies with single-target CAR-T cells. The treatment involves lymphodepletion with fludarabine and cyclophosphamide followed by a single infusion of the engineered T cells.
- Other names
- Biomarker-Guided Dual-Target CAR-T
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