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autologous EBV and oncogene-specific cytotoxic T lymphocytes
- Development stage
- Unknown
- Lead developer
- Memorial Sloan Kettering Cancer Center
- Modality
- Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
Autologous EBV and oncogene-specific cytotoxic T lymphocytes are a form of adoptive cell therapy in which a patient's own (autologous) T cells are collected, expanded ex vivo to specifically target antigens from the Epstein-Barr virus (EBV) and relevant oncogenes, then reinfused into the patient. These CTLs are predominantly CD3+ CD8+ cells that recognize and kill EBV-infected or tumorigenic cells expressing viral or oncogenic antigens. The therapy aims to restore or enhance cellular immune responses against chronic active EBV infection or malignancies associated with EBV/oncogene expression. Clinical studies have shown that this approach can resolve symptoms of chronic active EBV infection, normalize anti-EBV antibody titers, reduce viral load in transplant recipients at risk for posttransplantation lymphoproliferative disorders (PTLD), and control tumor growth in preclinical models[1][2][4][5]. The treatment is generally well tolerated with minimal toxicity reported.
- Other names
- autologous EBV-specific cytotoxic T lymphocytesautologous EBV-CTLsautologous Epstein-Barr virus–specific cytotoxic T cells
02
Targets
Peptide–Major Histocompatibility Complex class I (pMHC-I) presenting oncogene-derived tumor-associated antigenspMHC-I (Peptide–MHC class I complex)
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