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autologous Epstein-Barr virus-specific cytotoxic T lymphocytes (Northwestern University)
- Development stage
- Unknown
- Lead developer
- Northwestern University
- Modality
- Cell Therapies
- Administration
- Intravenous
01
Overview
Autologous Epstein-Barr virus-specific cytotoxic T lymphocytes (EBV-CTLs) are an adoptive cellular immunotherapy developed by **Northwestern University**. This therapy involves the ex vivo expansion of a patient's own T cells that have been specifically sensitized to recognize and eliminate cells infected with the **Epstein-Barr virus (EBV)**. It is primarily investigated for the treatment and prevention of EBV-induced **post-transplant lymphoproliferative disorder (PTLD)** in recipients of solid organ or hematopoietic stem cell transplants. By restoring EBV-specific immunity, these CTLs target EBV-positive B-cell proliferations, providing a targeted alternative to traditional chemotherapy or reduction of immunosuppression.
- Other names
- autologous EBV-CTLsautologous EBV-specific T cellsautologous EBV-specific cytotoxic T lymphocytes
02
Targets
pMHC (Peptide-MHC complex family)
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