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autologous fat-derived stromal vascular fraction
- Development stage
- Unknown
- Lead developer
- Rehabilitation College of Gannan Medical University
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intraarticular
01
Overview
Autologous fat-derived stromal vascular fraction (SVF) is a heterogeneous cellular concentrate obtained from a patient's own adipose tissue, typically through liposuction followed by enzymatic digestion or mechanical dissociation. This cell population includes mesenchymal stem cells (ADSCs), endothelial progenitor cells, pericytes, fibroblasts, and various immune cells such as macrophages and T cells. SVF is utilized in regenerative medicine for its ability to modulate inflammation, promote angiogenesis, and support tissue repair through the secretion of various paracrine factors and direct cellular interactions. In the treatment of knee osteoarthritis, SVF is administered via intra-articular injection to alleviate pain and improve joint function by reducing local inflammation and potentially stimulating cartilage maintenance.
- Other names
- stromal vascular fractionadipose-derived stromal vascular fractionautologous SVFfat-derived stromal vascular fraction
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