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autologous macrophage therapy
- Development stage
- Phase 2
- Lead developer
- Resolution Therapeutics
- Modality
- CAR-Macrophages → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
**Autologous macrophage therapy** is a personalized cell therapy involving the isolation of a patient's own monocytes, differentiation into macrophages *ex vivo* under Good Manufacturing Practice (GMP) conditions, and reinfusion into the patient. The primary mechanism is to harness the anti-inflammatory, pro-regenerative, and fibrosis-resolving properties of macrophages. This approach aims to reduce inflammation, promote tissue repair, and stimulate regeneration, particularly in diseases like liver cirrhosis. Preclinical and early clinical data suggest safety and potential efficacy, especially in reducing liver-related complications and improving outcomes in patients with advanced liver disease[1][2][4][7][8][9].
- Other names
- autologous monocyte-derived macrophage therapyautologous macrophage cell therapy
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