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autologous mesenchymal stem cells (Institute of Biophysics and Cell Engineering)
- Development stage
- Unknown
- Lead developer
- Institute of Biophysics and Cell Engineering
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intrauterine
01
Overview
This investigational autologous cell therapy is developed by the Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus for the treatment of recurrent pregnancy loss associated with endometrial hypoplasia (thin endometrium). The therapy involves the isolation and preparation of the patient's own mesenchymal stem cells (MSCs), which are then induced or selected for their ability to differentiate into endometrial and decidual cells. These cells are intended to be transplanted into the uterus to regenerate the endometrial lining, increase its thickness, and improve the uterine environment for embryo implantation and gestation. The program is currently being evaluated in a Phase 1/2 clinical trial (NCT05520112).
- Other names
- mesenchymal stem cells capable of differentiation in the endometrial-decidual directionautologous MSCs for recurrent pregnancy loss
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