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Autologous platelet gel is an investigational topical, autologous blood-derived biologic developed by National Healing Corporation for lower-extremity chronic venous insufficiency ulcers. The point-of-care product combines a patient-derived autologous platelet concentrate with topical thrombin to generate a platelet gel applied directly to the ulcer in addition to standard venous-ulcer care. Platelets provide a localized mixture of wound-healing growth factors, cytokines, and matrix-associated mediators intended to support granulation tissue formation, angiogenesis, re-epithelialization, and tissue repair. It was evaluated in the multicenter randomized study NCT00273234. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00273234))
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