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autologous platelet-rich plasma (Yantai Yuhuangding Hospital)
- Development stage
- Unknown
- Lead developer
- Yantai Yuhuangding Hospital
- Modality
- Cell Therapies
- Administration
- Intraarticular
01
Overview
Autologous platelet-rich plasma (PRP) is a concentrated preparation of platelets derived from a patient's own blood, containing a high density of growth factors and cytokines. These include platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF), which are released upon platelet activation. In the clinical trial conducted by Yantai Yuhuangding Hospital, PRP is administered via intra-articular injection for the treatment of severe knee osteoarthritis. The therapy aims to modulate the intra-articular inflammatory environment, promote tissue repair, and alleviate pain by stimulating cellular proliferation and angiogenesis. In this specific study context, it is evaluated both as a standalone treatment and as a scaffold for autologous adipose-derived mesenchymal stem cells (AMSCs).
- Other names
- PRPautologous PRP
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