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Autologous platelet-rich plasma (PRP) is a biologic therapy derived from a patient's own blood, concentrated to provide a high density of platelets. In the GO-PRP clinical trial conducted by the Rheumatology Department at Hospital St. Joseph in Marseille, France, this specific autologous preparation was evaluated for the treatment of symptomatic knee osteoarthritis resistant to first-line medical therapies. The preparation process utilizes a dedicated CE-marked medical device to produce a very pure PRP with high platelet concentrations and minimal contamination from red blood cells and leukocytes. Administered via intra-articular injection, the therapy works by releasing a variety of growth factors and bioactive molecules that modulate the joint environment, reduce inflammation, and promote tissue repair.
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