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autologous pooled platelet concentrate
- Development stage
- Unknown
- Lead developer
- Medizinische Universität Graz Open Science
- Modality
- Cell Therapies
- Administration
- Intravenous
01
Overview
Autologous pooled platelet concentrate is an investigational blood-derived biologic consisting of a patient's own platelets, collected and pooled for re-administration. Developed by the Medizinische Universität Graz, it is being studied in Phase 2 clinical trials as a reversal strategy for dual antiplatelet therapy (DAPT), specifically to counteract the effects of clopidogrel (a P2Y12 inhibitor) and aspirin (a COX-1 inhibitor). By transfusing functional, uninhibited autologous platelets, the product aims to restore ADP- and arachidonic acid-induced platelet aggregation, potentially providing a method to manage bleeding risks or prepare patients for urgent surgery while on antiplatelet medication.
- Other names
- autologous pooled platelet concentrates
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