autologous serum artificial tears

Autologous serum artificial tears are personalized ophthalmic solutions made from a patient's own blood. After blood is drawn and allowed to clot, the serum is separated by centrifugation and diluted with a sterile, preservative-free solution (commonly saline) to create eye drops that closely mimic the biochemical composition of natural human tears[3][4][5]. These drops contain growth factors, vitamins (such as vitamin A), albumin (with antioxidant properties), fibronectin, lysozyme, transforming growth factor-β (TGF-β), and other nutrients essential for ocular surface health[1][4][5]. The mechanism of action involves mimicking natural basal tear biochemistry to promote healing of the ocular surface epithelium and reduce inflammation[6]. Autologous serum artificial tears are primarily used for moderate-to-severe dry eye disease unresponsive to conventional therapies but are also indicated in severe ocular surface disorders such as Sjögren's syndrome-related tear deficiency, graft-versus-host disease-associated dry eye, neurotrophic keratitis, persistent epithelial defects (PED), Stevens-Johnson syndrome, chemical injuries/burns of the cornea/conjunctiva[1][4][9]. They have been shown in studies to improve tear production/stability and support corneal healing. Because they are derived from the patient’s own blood (“autologous”), risk of allergic reaction is minimized.

Brand names

Serum Tears

Other names

autologous serum tearsautologous serum eye dropsASEDsautologous serum drops