autologous serum tears + cyclosporin

Autologous serum tears + cyclosporin is a combination therapy used primarily for the treatment of moderate to severe dry eye disease, especially in cases refractory to conventional treatments. Autologous serum tears are blood-derived eye drops made from a patient's own blood, containing growth factors, vitamins (such as vitamin A), immunoglobulins, and other components that closely mimic natural basal tears and promote healing of the ocular surface epithelium[2][3][6][7]. Cyclosporin (commonly as 0.05% topical emulsion) is an immunomodulatory agent that inhibits T-cell activation and reduces ocular surface inflammation. The combination leverages the anti-inflammatory effects of cyclosporin with the epitheliotrophic and tear-mimicking properties of autologous serum, providing additive or synergistic benefits for patients with severe or persistent dry eye disease[5]. This regimen is particularly considered when monotherapy fails or in cases such as Sjögren's syndrome-related dry eye. Both agents are typically compounded under sterile conditions; autologous serum must be prepared by specialized compounding pharmacies or hospital facilities.

Other names

autologous serum + cyclosporineautologous serum eye drops + cyclosporineserum tears + cyclosporine