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autologous stem cell therapy (Andalusian Initiative for Advanced Therapies)

Development stage
Unknown
Lead developer
Red Andaluza de Terapias Avanzadas
Modality
Stem Cell Therapies → Cell Therapies
Administration
Intra-arterial
01

Overview

This autologous stem cell therapy is an advanced medicinal product developed by the Andalusian Initiative for Advanced Therapies (IATA) and the Fundación Pública Andaluza Progreso y Salud. It involves the intra-arterial administration of patient-derived cells, specifically comparing the efficacy of bone marrow mononuclear cells (BM-MNCs), CD133+ endothelial progenitor cells (EPCs), and adipose-derived mesenchymal stem cells (AD-MSCs). The therapy is primarily indicated for patients with type 2 diabetes mellitus suffering from critical limb ischemia (CLI). Its mechanism of action centers on stimulating neovascularization and therapeutic angiogenesis to restore blood flow to ischemic tissues, thereby reducing the risk of major amputation. Additionally, the therapy aims to modulate inflammatory cytokines and improve insulin sensitivity, potentially reducing the patient's exogenous insulin requirements.

Other names
stem cell-Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud-critical limb ischemia-type 2 diabetes mellitusStem cell infusionBM-MNCsCD133+ EPCsAD-MSCs

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