autologous stromal vascular fraction of adipose tissue

Autologous stromal vascular fraction (SVF) of adipose tissue is an investigational cell-based biologic therapy developed by Assistance Publique Hôpitaux de Marseille (AP-HM). It consists of a heterogeneous mixture of cells obtained from a patient's own adipose tissue via lipoaspiration followed by enzymatic digestion and centrifugation. This mixture is enriched with mesenchymal stem/stromal cells (MSCs), endothelial progenitor cells, pericytes, and various immune cells. The therapy exerts its therapeutic effects through paracrine signaling and direct cell-to-cell interactions that promote angiogenesis, reduce inflammation, and stimulate tissue regeneration. It is primarily being evaluated in Phase 2 clinical trials for the treatment of chronic, refractory diabetic foot ulcers, as well as for hand disability and digital ulcers in systemic sclerosis and vocal fold scarring.

Other names

autologous adipose-derived stromal vascular fractionautologous SVF