Drug intelligence / Profile preview

AVA-ERL

Development stage
Preclinical
Lead developer
Avammune Therapeutics
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
01

Overview

AVA-ERL is a first-in-class tumor-targeted radioligand therapy (RLT) being developed by Avammune Therapeutics. It is designed to deliver a radioactive payload specifically to tumor cells by binding to a proprietary target. The drug is currently in the discovery stage for the treatment of hepatocellular carcinoma (HCC) and renal cell carcinoma (RCC). As a radioligand therapy, it utilizes a targeting ligand to deliver a cytotoxic radioactive isotope directly to cancer cells, minimizing damage to healthy tissues.

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