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avanafil
- Development stage
- Approved
- Lead developer
- VIVUS LLC
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Avanafil is a small molecule drug used to treat erectile dysfunction (ED) in men. It belongs to the class of phosphodiesterase type 5 (PDE5) inhibitors, which work by blocking the PDE5 enzyme in penile tissue. This inhibition increases levels of cyclic guanosine monophosphate (cGMP), leading to relaxation of smooth muscle and increased blood flow to the penis during sexual stimulation, resulting in an erection. Avanafil is known for its rapid onset and high selectivity for PDE5 compared to other subtypes, potentially reducing certain side effects seen with less selective agents. The drug was developed as a fast-acting option for ED and has been approved by regulatory agencies such as the US FDA[1][2][3][5].
- Brand names
- Stendra
- Other names
- avanafil
02
Targets
PDE5 (Phosphodiesterase 5A)
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