avanafil + amlodipine

Avanafil + amlodipine is a combination of two pharmaceutical drugs, each with distinct mechanisms of action and clinical uses. Avanafil is a phosphodiesterase type 5 (PDE5) inhibitor indicated for the treatment of erectile dysfunction in adult males. It works by selectively inhibiting PDE5, leading to increased levels of cGMP in the corpus cavernosum during sexual stimulation, resulting in smooth muscle relaxation and enhanced blood flow to the penis[4][6][8]. Amlodipine is a dihydropyridine calcium channel blocker used primarily for treating high blood pressure (hypertension), angina (chest pain), and coronary artery disease. It acts as a peripheral arterial vasodilator by inhibiting calcium ion influx into vascular smooth muscle and cardiac muscle cells, thereby reducing peripheral vascular resistance and lowering blood pressure[1][2][7]. The combination may be considered when both indications—erectile dysfunction and hypertension or angina—are present; however, caution is advised due to potential additive effects on lowering blood pressure[3].

Brand names

Spedra