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Avanz Salsola kali
- Development stage
- Phase 2
- Lead developer
- ALK Abelló
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
Avanz Salsola kali is a subcutaneous immunotherapy (SCIT) product developed by ALK-Abelló for the treatment of IgE-mediated allergic rhinitis and conjunctivitis caused by *Salsola kali* (Russian thistle) pollen. The product consists of standardized allergen extracts adsorbed onto aluminum hydroxide, which acts as an adjuvant to provide a depot effect, allowing for a gradual release of the allergen. The mechanism of action involves inducing allergen-specific immune tolerance by modulating the immune system's response, typically characterized by a shift from a Th2-dominated allergic response to a Th1/Treg-dominated profile, an increase in allergen-specific IgG4 'blocking' antibodies, and a reduction in the sensitivity of mast cells and basophils to the allergen.
- Brand names
- Avanz
- Other names
- Salsola kali pollen allergen extractRussian thistle pollen allergen extractAvanz Salsola
02
Targets
Salsola kali pollen allergen (Sal k 1)Profilin Sal k 4
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