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AVAT-122

Development stage: Unknown
Lead developer: Avata Biosciences
Modality: Small Molecules
Administration: Oral

Overview

AVAT-122 (formerly SAP-022) is an aqueous solution formulation of synthetic cannabidiol (CBD) being developed by Avata Biosciences (formerly Sapient Therapeutics) for the treatment of pediatric focal epilepsy. Utilizing Avata's proprietary water-soluble cannabinoid formulation technology, AVAT-122 is designed to improve the bioavailability and delivery of cannabidiol without the use of oil, alcohol, or THC. Cannabidiol acts as a multi-target modulator, primarily targeting cannabinoid receptors 1 and 2 (CB1 and CB2), G-protein coupled receptor 55 (GPR55), and transient receptor potential vanilloid type 1 (TRPV1) channels to reduce neuronal hyperexcitability. AVAT-122 is currently in Phase 1 clinical development.

Other names: cannabidiol aqueous solutionsynthetic cannabidiol aqueous solution

Targets

TRPV1 (Transient receptor potential cation channel subfamily V member 1)GPR55 (G protein-coupled receptor 55)ENT1 (Solute carrier family 29 member 1)CNR2 (Cannabinoid receptor type 2)

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