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AVC-S-201
- Development stage
- Preclinical
- Lead developer
- Avidicure
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Monoclonal Antibodies → Antibody-Based Therapeutics
01
Overview
AVC-S-201 is a preclinical-stage, triple-agonistic monoclonal antibody (Actibody) developed by Avidicure for the treatment of acute myeloid leukemia (AML) and other hematologic and solid tumors. Built on a human IgG scaffold, the Actibody platform genetically fuses two proprietary domains to provide three essential signals for immune activation: primary activation (Signal 1), co-stimulation (Signal 2), and cytokine signaling (Signal 3). This multifunctional modality is designed to be functional only within the immunological synapse between immune cells (specifically γδ T cells) and target cancer cells, thereby minimizing systemic toxicity while maximizing local immune response.
- Other names
- Actibody
02
Targets
γδ TCR (T-cell receptor)
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