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AVCETP
- Development stage
- Preclinical
- Lead developer
- Avesthagen
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
AVCETP is a biosimilar monoclonal antibody being developed by Avestha Gengraine Technologies (Avesthagen) for the treatment of HER2-positive breast cancer. As a biosimilar to trastuzumab (Herceptin), it is designed to bind to the extracellular domain of the Human Epidermal Growth Factor Receptor 2 (HER2/ERBB2). By binding to HER2, the antibody inhibits ligand-independent HER2-driven signaling pathways, such as the PI3K/Akt and MAPK pathways, which are critical for tumor cell proliferation and survival. Additionally, it mediates antibody-dependent cellular cytotoxicity (ADCC) through its Fc region, recruiting immune effector cells to destroy the target cancer cells. The drug is part of Avesthagen's biopharmaceutical portfolio targeting emerging markets.
- Brand names
- AVCETP
- Other names
- trastuzumab biosimilarHerceptin biosimilarAvesthagen HER2 biosimilar
02
Targets
ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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