avenanthramide B

Avenanthramide B is a naturally occurring phenolic alkaloid found primarily in oats (*Avena sativa*). It is a conjugate of ferulic acid and 5-hydroxyanthranilic acid. Biologically, it acts as a potent anti-inflammatory agent by inhibiting the **NF-κB** (nuclear factor kappa B) pathway, thereby reducing the expression of pro-inflammatory cytokines. It also exhibits antioxidant, anti-itch, and anti-melanogenic properties, the latter through the inhibition of tyrosinase and melanogenesis. While it is a key active component in FDA-approved colloidal oatmeal skin protectants used for conditions like atopic dermatitis and eczema, avenanthramide B itself is primarily utilized as a research tool and analytical standard in studies concerning cardiovascular health (atherosclerosis), oncology, and dermatology.

Other names

N-feruloyl-5-hydroxyanthranilic acidN-feruloyl5-hydroxyanthranilic acidN-feruloyl 5-hydroxyanthranilic acid5-Hydroxy-2-{[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propenyl]amino}benzoic acidAvenanthramide 2fAvenanthramide2fAvenanthramide-2fCAS 108605-69-2CAS108605-69-2CAS-108605-69-2