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AVI-7537
- Development stage
- Discontinued
- Lead developer
- Sarepta Therapeutics
- Modality
- MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
AVI-7537 is an antisense phosphorodiamidate morpholino oligomer (PMOplus) designed to inhibit Ebola virus replication. It specifically targets the mRNA of the Ebola virus VP24 gene, blocking its translation and thereby preventing viral replication. Developed as a single agent after initial combination studies, AVI-7537 was investigated for use against Ebola virus disease and advanced into clinical trials, including Phase 1 studies in healthy volunteers. The drug was developed by Sarepta Therapeutics and represents a targeted antiviral approach using antisense oligonucleotide technology.
02
Targets
VP24 (Ebola virus VP24)vRNA (Coronavirus viral RNA)
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