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Avidekel Oil
- Development stage
- Phase 3
- Lead developer
- Tikun Olam
- Modality
- Small Molecules
- Administration
- Oral, Sublingual
01
Overview
Avidekel Oil is a high-cannabidiol (CBD) medical cannabis oil formulation developed by Tikun Olam. It is derived from the proprietary Avidekel cannabis strain, which is characterized by a high CBD-to-THC ratio (typically 30:1), ensuring therapeutic effects without significant psychoactivity. The oil is primarily investigated for managing behavioral and psychological symptoms of dementia (BPSD), such as agitation, aggression, and sleep disturbances in patients with Alzheimer's disease. Its mechanism of action involves the modulation of the endocannabinoid system through cannabinoid receptors (CB1 and CB2) and interactions with non-cannabinoid targets, including the serotonin 5-HT1A receptor and the TRPV1 cation channel, which contribute to its calming, anti-inflammatory, and neuroprotective properties.
- Brand names
- Avidekel Oil
- Other names
- Avidekel
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))CNR1 (Cannabinoid receptor 1)CNR2 (Cannabinoid receptor type 2)TRPV1 (Transient receptor potential cation channel subfamily V member 1)
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