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Avirus
- Development stage
- Unknown
- Lead developer
- ChemRar Research and Development Institute
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Avirus is an experimental small molecule antiviral agent developed by the ChemRar Research and Development Institute for the treatment of chronic hepatitis C virus (HCV) infection. It is characterized as a multi-target inhibitor that simultaneously acts on two critical components of the HCV replication machinery: the nonstructural protein 5A (NS5A) and the nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase. By targeting multiple stages of the viral life cycle with a single molecule, Avirus is intended to provide high efficacy across various HCV genotypes and increase the genetic barrier to the development of drug resistance. The candidate is currently undergoing Phase 2 clinical trials to evaluate its safety and antiviral activity in patients with chronic HCV.
- Other names
- АвирусAVIRUS
02
Targets
NS5A (Hepatitis C virus nonstructural protein 5A (genotype 1b))NS5B (Hepatitis C virus non-structural protein 5B (NS5B) RNA-dependent RNA polymerase)
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