aviscumine

Aviscumine is a recombinant form of mistletoe lectin I, originally derived from the plant Viscum album. It functions as a ribosome-inactivating protein that binds to the cell surface sialyltransferase CD75 and is internalized into cells, where it cleaves an adenine-specific N-glycosidic bond on the 28S ribosomal subunit. This action inhibits ribosomal activity, disrupts protein synthesis, and induces apoptosis in tumor cells[1][5]. Aviscumine also acts as an immunomodulatory agent by enhancing natural killer (NK) cell cytotoxicity and increasing levels of interleukins in nontumor cells[3][5][6]. It has been investigated primarily for its antitumor effects in various solid tumors including malignant melanoma, colorectal cancer, bladder cancer, malignant pleural effusion, glioblastoma, liver cancer, lung cancer, and sarcoma[4]. Clinical development has reached phase II for some indications.

Other names

aviscuminemistletoe lectin recombinantrecombinant mistletoe lectinrecombinant viscuminrecombinant viscuminerViscuminViscum ribosome inactivating protein