Drug intelligence / Profile preview

avocado and soyabean oil, unsaponifiables

Development stage
Unknown
Lead developer
Gramón Bagó
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Artrisedol is an anti-osteoarthritis pharmaceutical product developed and marketed by Gramón Bagó in Uruguay. It is formulated as oral capsules containing 300 mg of avocado and soybean unsaponifiables (ASU), consisting of a 1:2 ratio of avocado oil unsaponifiables (100 mg) and soybean oil unsaponifiables (200 mg). Artrisedol acts as a symptomatic slow-acting drug for osteoarthritis (SYSADOA). It helps restore the balance between the degradation and regeneration of the extracellular matrix in joint cartilage by stimulating the synthesis of collagen and proteoglycans, while reducing the production of fibronectin, pro-inflammatory cytokines (such as IL-1β and TNF-α), and matrix metalloproteinases (MMPs). It is primarily indicated for the treatment of osteoarthritis of the knee and hip, and as an adjunct treatment for periodontal disease.

Brand names
ArtrisedolArtrisedol 300Artrisedol300Artrisedol-300
Other names
ASUavocado and soybean unsaponifiablesavocado soybean unsaponifiablesinsaponificables de aguacate y sojainsaponificables de palta y soja
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)IL-6 (Interleukin 6)MMP13 (Matrix metalloproteinase-13)MMP3 (Matrix metalloproteinase-3)PTGES (Microsomal prostaglandin E synthase-1)NOS2 (Nitric Oxide Synthase 2)

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