avocado soybean unsaponifiables

Piascledine is a symptomatic slow-acting drug for osteoarthritis (SYSADOA) composed of a specific ratio of avocado and soybean oil unsaponifiables (1:2). Developed by Laboratoires Expanscience and marketed by Austell in South Africa, it is indicated for the relief of symptoms associated with osteoarthritis of the knee and hip. Its mechanism of action involves the inhibition of pro-inflammatory cytokines, particularly interleukin-1 (IL-1), and the reduction of matrix metalloproteinases (MMPs) and prostaglandin E2 (PGE2) production in chondrocytes. Simultaneously, it promotes the synthesis of extracellular matrix components such as collagen and proteoglycans by increasing the expression of transforming growth factor-beta (TGF-β). This dual action helps to reduce joint pain and stiffness while potentially slowing the degradation of joint cartilage.

Brand names

PiascledinePiascledine 300Piascledine300Piascledine-300

Other names

ASUavocado and soybean unsaponifiables