avocado-soybean unsaponifiables

Avocado-soybean unsaponifiables is a natural vegetable extract composed of the unsaponifiable fractions of avocado and soybean oils, typically in a 1:2 ratio. It is used primarily as a symptomatic slow-acting drug in osteoarthritis (SYSADOA) for hip and knee osteoarthritis, but also considered for scleroderma, menopause-related symptoms, and other conditions[1][3][5][8]. ASU is chondroprotective, anti-inflammatory, anabolic, and anticatabolic—stimulating collagen and proteoglycan synthesis, decreasing matrix metalloproteinase activity, reducing pro-inflammatory cytokine production (such as IL-1, IL-6, TNF-alpha), and blocking COX-2 expression and PGE2 secretion. Its principal active components include phytosterols (beta-sitosterol, campesterol, stigmasterol), isoflavones, tocopherols, and squalene[1][3]. Its mechanism of action is not fully understood but is thought to act by modulating connective tissue metabolism and reducing inflammatory mediators in articular joints[1][3][8].

Brand names

Piascledine

Other names

avocado/soybean unsaponifiablesavocado soy unsaponifiablesavocado/soy unsaponifiablesArthrocen