avocadyne

Avocadyne is a **polyhydroxylated fatty alcohol** (C₁₇H₃₂O₃) of natural origin, primarily extracted from avocado (*Persea americana*). Structurally, it is distinguished as a 17-carbon terminally unsaturated acetogenin, featuring a triple bond at the terminal carbon and hydroxyl groups at carbons 1, 2, and 4. Avocadyne exhibits **potent bioactivity through direct inhibition of very long chain acyl-CoA dehydrogenase (VLCAD)**, a key mitochondrial enzyme in the **fatty acid oxidation (FAO) pathway**. This action disrupts energy generation in **acute myeloid leukemia (AML) cells**, leading to selective induction of apoptosis in malignant, but not normal, hematopoietic cells. Preclinical evidence also supports roles in enhancing **insulin sensitivity** and **improving glucose tolerance**, with potential application in the management of diabetes. Avocadyne has shown **antiviral properties** in preclinical studies. Its presence is documented both in avocado pulp and seeds, and it is being explored as a candidate for pharmaceutical and dietary supplement use for AML and metabolic diseases[1][2][3][4][7][8].

Other names

16-heptadecyne-1,2,4-triolheptadec-16-yne-1,2,4-triolheptadecane-16-yne-1,2,4-triol1,2,4-trihydroxyheptadec-16-yne