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AVT-011
- Development stage
- Unknown
- Lead developer
- Avaant Imaging
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
AVT-011 is a fluorine-18 labeled positron emission tomography (PET) radiotracer designed to non-invasively image and quantify the function of ATP-binding cassette (ABC) efflux transporters, specifically P-glycoprotein (Pgp/ABCB1) and breast cancer resistance protein (BCRP/ABCG2). Developed by Avaant Imaging in collaboration with academic institutions including the University of Oxford, Karolinska Institutet, UCLA, and NIMHANS, AVT-011 acts as a dual ABCB1/ABCG2 substrate. It is utilized to detect and monitor multidrug resistance (MDR) and chemoresistance in tumors, such as breast cancer, as well as to evaluate transporter function at the blood-brain barrier.
- Other names
- [18F]-AVT-011[18F]AVT-011[18F]F-AVT-011fluorine-18-AVT-011fluorine18-AVT-011fluorine 18-AVT-011
02
Targets
ABCG2 (Breast cancer resistance protein)ABCB1 (P-glycoprotein)
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