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AX251
- Development stage
- Phase 1
- Lead developer
- Anxo Pharmaceutical
- Modality
- Small Molecules
- Administration
- Intramuscular
01
Overview
AX251 is a long-acting injectable (LAI) formulation of cariprazine, an atypical antipsychotic, being developed by Anxo Pharmaceutical Co., Ltd. for the treatment of schizophrenia. Cariprazine, the active moiety, functions as a partial agonist at dopamine D3 and D2 receptors, with a notably high affinity for the D3 subtype, and as a partial agonist at serotonin 5-HT1A receptors. The LAI formulation is designed to improve treatment adherence and provide stable therapeutic drug levels over an extended period compared to daily oral administration. AX251 is currently in Phase 1 clinical development, where it is being evaluated for its pharmacokinetics, safety, and tolerability in patients with clinically stable schizophrenia.
- Other names
- cariprazine long-acting injectable
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR2A (Serotonin receptor 5-HT2A)HTR2B (5-Hydroxytryptamine Receptor 2B)DRD2 (Dopamine D2 Receptor)DRD3 (Dopamine receptor D3)
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