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AX251 LAI

Development stage: Unknown
Lead developer: Anxo Pharmaceutical
Modality: Small Molecules
Administration: Intramuscular

Overview

AX251 LAI is a long-acting injectable (LAI) formulation of cariprazine, an atypical antipsychotic, being developed by Anxo Pharmaceutical for the treatment of schizophrenia. Cariprazine acts as a potent dopamine D3 and D2 receptor partial agonist, with a higher affinity for the D3 receptor, and as a serotonin 5-HT1A receptor partial agonist. The LAI formulation is designed to improve patient adherence by providing sustained therapeutic levels of the drug over an extended period compared to daily oral administration. It is currently in Phase 1 clinical development to evaluate its pharmacokinetics, safety, and tolerability in patients with clinically stable schizophrenia.

Other names: cariprazine long-acting injectable

Targets

HTR2A (Serotonin receptor 5-HT2A)DRD2 (Dopamine D2 Receptor)DRD3 (Dopamine receptor D3)HTR2B (5-Hydroxytryptamine Receptor 2B)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))

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