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AXB-10507
- Development stage
- Preclinical
- Lead developer
- Alexion Pharmaceuticals
- Modality
- Nanobodies (VHH) → Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Subcutaneous
01
Overview
AXB-10507 is a rat surrogate bispecific VHH (heavy-chain variable domain) antibody targeting rat properdin (factor P, fP) and serum albumin. Developed by Alexion (AstraZeneca Rare Disease), AXB-10507 is used as a preclinical tool to evaluate the therapeutic potential of properdin inhibition, serving as a surrogate for the clinical-stage humanized bispecific VHH antibody ALXN1820 (tarperprumig). AXB-10507 selectively inhibits alternative pathway (AP) complement activation by preventing C3/C5 convertase formation. In preclinical models of experimental autoimmune vasculitis (EAV), subcutaneous administration of AXB-10507 significantly reduced hematuria and proteinuria, and protected against glomerular and tubular damage.
02
Targets
CFP (Complement factor properdin)
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