Drug intelligence / Profile preview

AxisBiotix-Ps

Development stage
Unknown
Lead developer
SkinBioTherapeutics
Modality
Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
Administration
Oral
01

Overview

AxisBiotix-Ps is a probiotic food supplement developed by SkinBioTherapeutics, through its subsidiary AxisBiotix, in partnership with Winclove Probiotics B.V. for the treatment of psoriasis. [4] Now also marketed as AxisBiotix Skin Calm, the product's active ingredient is a proprietary blend of four live bacteria strains: Bifidobacterium animalis, Levilactobacillus brevis, Limosilactobacillus reuteri, and Lactococcus lactis cremoris. [3] Each sachet contains approximately 4 billion live bacteria. [3] Classified as a biologic modality (probiotic), its biological targets are the pro-inflammatory cytokines Interleukin-17 (IL-17) and Interleukin-23 (IL-23), which are typically elevated in individuals with psoriasis. [3] The supplement operates through the gut-skin axis to modulate the immune system, reduce inflammation, and strengthen the gut barrier, thereby aiming to alleviate psoriasis symptoms such as redness, itchiness, and flaky skin. [3] It is marketed as a non-prescription food supplement available in powder form and was launched in the UK and US in 2021, followed by launches in Spain and Italy. [8, 9, 12]

Brand names
AxisBiotix-PsAxisBiotix Skin Calm
02

Targets

IL-17A (Interleukin-17A)IL-23 (Interleukin-23)

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