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axitinib implant
- Development stage
- Phase 2
- Lead developer
- Alcon
- Modality
- Implantable Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules
- Administration
- Intravitreal, Ophthalmic
01
Overview
Axitinib implant (AR-14034 SR) is a **sustained-release retinal implant** developed by Aerie Pharmaceuticals (now part of Alcon) for intravitreal administration. It delivers the small molecule drug axitinib, a **pan-VEGF receptor inhibitor**, through a bio-erodible polymer blend using PRINT technology. The implant is designed to provide long-term suppression of VEGF-mediated angiogenesis in retinal diseases.
- Other names
- AR-14034 Sustained Release ImplantAR14034 Sustained Release ImplantAR 14034 Sustained Release Implant
02
Targets
VEGFR2 (Vascular endothelial growth factor receptor 2)KIT (c-KIT proto-oncogene receptor tyrosine kinase)PDGFRB (Platelet-derived growth factor receptor beta)TEK (Tie2)VEGFR3 (Vascular endothelial growth factor receptor 3)VEGFR-1 (Vascular endothelial growth factor receptor 1)
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