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Axl-DM1 sdAb ADC
- Development stage
- Preclinical
- Lead developer
- National Research Council of Canada
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Axl-DM1 sdAb ADC is a preclinical antibody-drug conjugate (ADC) developed by the National Research Council (NRC) of Canada. It consists of a llama-derived single domain antibody (sdAb) targeting the extracellular domain of the AXL receptor tyrosine kinase, conjugated to the cytotoxic maytansine derivative DM1 via a noncleavable linker. AXL is a member of the Tyro3-AXL-Mer (TAM) receptor tyrosine kinase subfamily and is overexpressed in multiple cancers including breast, lung, ovarian, gastric, and prostate cancers. The drug demonstrated sub-nanomolar cytotoxic potency in vitro against AXL-expressing breast (MDA-MB 231), lung (NCI-H292), and ovarian (SKOV3) cancer cell lines, and showed potent anti-tumor activity in vivo in xenograft models.
- Other names
- anti-AXL-DM1 sdAb ADCanti-AXL-DM-1 sdAb ADCanti-AXL-DM 1 sdAb ADCAxl-DM1 ADCAxl-DM-1 ADCAxl-DM 1 ADC
02
Targets
TUBB (Tubulin (alpha and beta subunits))AXL (AXL receptor tyrosine kinase)
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