Drug intelligence / Profile preview

ayahuasca tea

Development stage
Preclinical
Lead developer
Sacred Medicines
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Ayahuasca tea is a traditional psychoactive botanical brew native to the Amazon basin, prepared from the vine *Banisteriopsis caapi* and the leaves of *Psychotria viridis* (or other DMT-containing plants). It is being developed as a standardized botanical drug product by Sacred Medicines and the Advanced Integrative Medical Science (AIMS) Institute. The tea contains two primary active components: N,N-dimethyltryptamine (DMT), a potent psychedelic, and harmala alkaloids (such as harmine, harmaline, and tetrahydroharmine), which act as reversible monoamine oxidase A (MAO-A) inhibitors. The MAO inhibition prevents the peripheral degradation of DMT, allowing it to reach the central nervous system and exert its effects. Ayahuasca tea is being investigated in the United States for the treatment of treatment-resistant depression, anxiety, post-traumatic stress disorder (PTSD), substance use disorders, and existential distress in late-stage oncology patients.

Other names
ayahuascadaime teahoascayagéyaje
02

Targets

HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR2A (Serotonin receptor 5-HT2A)5-HT2C (5-hydroxytryptamine receptor 2C)SIGMAR1 (Sigma non-opioid intracellular receptor 1)HTR2C (5-hydroxytryptamine 2C receptor)MAOA (Monoamine oxidase A)

Beyond the preview

Go deeper on ayahuasca tea.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on ayahuasca tea.

Gosset Free

Get started with Gosset.

Enter your corporate email.

Work email preferred.

Book a call