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Ayurved Siriraj Prasaplai + mefenamic acid
- Development stage
- Unknown
- Lead developer
- Center of Applied Thai Traditional Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Ayurved Siriraj Prasaplai + mefenamic acid is a combination therapy consisting of a standardized Thai traditional herbal formulation (Prasaplai, specifically the "Ayurved Siriraj" version) and the nonsteroidal anti-inflammatory drug (NSAID) mefenamic acid. This combination is primarily used for the treatment of primary dysmenorrhea (painful menstruation). - **Prasaplai** is a multi-herb formula traditionally used in Thai medicine to regulate menstrual flow and relieve menstrual pain. Its mechanism includes anti-inflammatory effects, cyclooxygenase inhibition, antispasmodic activity on uterine muscle, and possible hormonal modulation[1][3][4]. - **Mefenamic acid** is an NSAID that provides analgesic and anti-inflammatory effects by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing prostaglandin synthesis associated with pain and inflammation[6][8][10]. Clinical studies have shown that both components individually are effective for dysmenorrhea; their combination may offer additive or synergistic benefits in pain relief during menstruation[1][2][7].
- Brand names
- Ayurved Siriraj Prasaplai + mefenamic acid
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)
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