aza-resveratrol

Aza-resveratrol (3,4',5-trihydroxy-trans-aza-stilbene) is a synthetic imine analog of the natural phytoalexin resveratrol. Developed by researchers at Kindai University and Kumamoto Health Science University, aza-resveratrol acts as a potent inhibitor of macrophage migration inhibitory factor (MIF) tautomerase activity. By binding directly to MIF, it prevents the cytokine from interacting with its cell surface receptor, CD74, thereby inhibiting MIF-mediated cell proliferation and signaling. Aza-resveratrol has demonstrated enhanced anti-proliferative activity compared to resveratrol in breast cancer cell lines (such as MCF-7) and is being investigated as a potential therapeutic agent for the treatment of cancer, inflammatory diseases, and autoimmune disorders.

Other names

3,4',5-trihydroxy-trans-aza-stilbeneaza-stilbene