AZA1

AZA1 is a small molecule dual inhibitor of the Rho GTPases **Rac1** and **Cdc42**. It functions by preventing the activation of these proteins, thereby disrupting downstream signaling pathways such as the p21-activated kinase (PAK) pathway. In preclinical research, particularly in pancreatic cancer models, AZA1 has been shown to sensitize cells to ionizing radiation by inhibiting the DNA damage response. Specifically, it blocks the activation of the ATM/Chk2 and ATR/Chk1 signaling axes, which leads to the abrogation of the radiation-induced G2/M cell cycle checkpoint and delays the repair of double-stranded DNA breaks. AZA1 is primarily utilized as a research tool to investigate the role of Rho GTPase signaling in tumor progression and therapy resistance.

Other names

N2,N4-bis(2,4-dimethylquinolin-6-yl)pyrimidine-2,4-diamine