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azacitidine + tislelizumab
- Development stage
- Unknown
- Lead developer
- BeiGene
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous, Subcutaneous
01
Overview
Azacitidine + tislelizumab is an investigational combination therapy consisting of azacitidine, a DNA methyltransferase inhibitor (epigenetic modulator), and tislelizumab, a monoclonal antibody targeting programmed cell death protein 1 (PD-1). Azacitidine works by inhibiting DNA methylation, leading to reactivation of tumor suppressor genes and increased cancer cell death. Tislelizumab is an immune checkpoint inhibitor that blocks PD-1 on T cells, preventing cancer cells from evading immune detection and destruction. This combination aims to enhance antitumor immunity by both modifying the tumor microenvironment with azacitidine and unleashing immune responses with PD-1 blockade via tislelizumab. The combination is under clinical investigation for various advanced solid tumors and hematologic malignancies.
- Brand names
- TevimbraVidazaOnureg
- Other names
- azacitidine + tislelizumabaza + tislelizumab
02
Targets
DNMT3A (DNA methyltransferase 3 alpha)DNMT1 (DNA (cytosine-5)-methyltransferase 1)PDCD1 (Programmed cell death protein 1 receptor)DNMT3B (DNA (cytosine-5)-methyltransferase 3B)
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